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SAN FRANCISCO -- Imipramine is effective and cheaper than more common drug therapies for treating overactive bladder, Dr. Karolynn T. Echols reported at the annual meeting of the American Urogynecologic Society.
The most common pharmacologic treatments for overactive bladder--oral oxybutynin and tolterodine--are available in extended-release formulations that have been reported to improve compliance and reduce their anticholinergic side effects. Not everyone can afford them, however, especially uninsured or indigent populations.
The cheaper tricyclic antidepressant imipramine, which has been shown to be effective in managing nocturnal enuresis, also has successfully treated overactive bladder symptoms in patients taking the drug for depression, said Dr. Karolynn T. Echols of Louisiana State University, New Orleans.
Her institution considers imipramine the first-line treatment option for overactive bladder.
In a retrospective study of records on 267 patients treated for overactive bladder over a 7-year period, results showed no significant differences in patient improvement or satisfaction between 165 patients given imipramine, 22 on oxybutynin, and 4 treated with tolterodine, she said. In the imipramine group, ...