AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Breast cancer patients often fare better with dense-dose chemotherapy regimen. (Boosted Survival 26%).
SAN ANTONIO -- Many women with lymph node--positive breast cancer are likely to receive chemotherapy on a novel compressed schedule as a result of a major clinical trial showing that this markedly improves outcomes.
Moreover, this successful clinical confirmation of the superiority of dense dosing, as it is called, may have major implications for chemotherapy in numerous other cancers, including gynecologic malignancies. Dense dosing may also have applications in a broad range of noncancerous diseases, although each potential new application will need to be studied in turn, Dr. Marc L. Citron said at a breast cancer symposium sponsored by the San Antonio Cancer Institute.
Dense dosing boosted disease-free survival by 26%, compared with conventional adjunctive chemotherapy schedules in a National Cancer Institute--sponsored randomized trial involving 1,973 surgically treated nodepositive breast cancer patients with no other metastases. Disease-free survival--the primary study end point--was 82% at 4 years in dense-dosed patients, compared with 75% for those who got identical cumulative doses of doxorubicin, paclitaxel, and cyclophosphamide on a conventional schedule.
Overall survival after 3 years was 92% in patients who received dense-dose chemotherapy, compared with 90% in those on conventional chemotherapeutic regimens. This translates into an adjusted 31% reduction in the relative risk of mortality, although longer follow-up will be needed to be sure of the true size of this effect, said Dr. Citron, lead investigator in the trial and an oncologist at Albert Einstein College of Medicine in New York.
A further advantage of dense-dose chemotherapy is that it shortens the duration of a complete course of chemotherapy from 24 to 16 weeks, enabling patients to bid an earlier goodbye to the nausea, vomiting, and other chemotherapy-related unpleasantness and get on with their lives.
Dense dosing involves administration of standard doses of ...
- Breast cancer survival improved by 'dense' dosing. (News Briefs).
- Newspaper article from: Drug Utilization Review February 1, 2003 700+ words
...toxicity in women with node-positive breast cancer, according to new research. The study...announced at the annual San Antonio Breast Cancer Symposium in December. "These findings...enrolled 2,005 women with primary breast cancer that had spread to the lymph nodes...
- Breast Cancer Survivor Jaclyn Smith Urges Women to Know Their Breast Cancer...
- Press release article from: PR Newswire July 10, 2007 700+ words
-- Breast Cancer Risk Factors Include Age, Family...entrepreneur, philanthropist and breast cancer survivor, is touring the country...Knowing: The Facts and Fiction of Breast Cancer Risk program, sharing her experience...
- Breast Cancer Research Stamp Funding the Fight to Find a Cure for a Decade;...
- News wire article from: AScribe Health News Service July 29, 2008 700+ words
...out of Washington today in the fight against breast cancer. The Breast Cancer Research Stamp is the first postage stamp of...Rodham Clinton. Since that historic day, the Breast Cancer Research Stamp has raised more money than any...
- Breast cancer risk and immune responses in healthy women.(Clinical report)
- Magazine article from: Oncology Nursing Forum Park, Na-Jin Kang, Duck-Hee November 1, 2006 700+ words
...findings of objective and subjective breast cancer risk assessments and their association...healthy women with a family history of breast cancer. Data Sources: Published articles...Healthy women with a family history of breast cancer have shown decreased immune responses...
- Breast cancer. (Letters to the Editor).
- Magazine article from: Townsend Letter for Doctors and Patients October 1, 2002 700+ words
...will see about 46,000 deaths from breast cancer It should be possible to reduce this...today is that the primary cause of breast cancer is estrogen. I have maintained a 30...report with the title of "Diet and Breast Cancer: The Possible Connection with Sugar...
- Breast Cancer Research Foundation Supports OSU Comprehensive Cancer Center's...
- News wire article from: Ascribe Higher Education News Service October 7, 2002 700+ words
...is receiving a second award from The Breast Cancer Research Foundation (BCRF) to continue...into the relationship between diet and breast cancer prevention. Dr. Electra Paskett...conducted under the auspices of the new Breast Cancer Prevention Through Nutrition Program...
- Breast Cancer Survivors Carry Optimistic Outlook on Life, Yet Lack Critical...
- News wire article from: Ascribe Higher Education News Service September 25, 2007 700+ words
...AScribe Newswire) -- The majority of breast cancer survivors consider themselves stronger...States who had been diagnosed with breast cancer. The vast majority (92 percent...10 (87 percent) said that having breast cancer made them a stronger person and about...
- Breast cancer update: what-really reduces your risk: the pill. Coffee. Sun....
- Magazine article from: Redbook Levine, Hallie October 1, 2002 700+ words
...habits are upping our odds of getting breast cancer. And it's no wonder we're confused...study tells us what to eat to prevent breast cancer; the next week, another tells us...myths? What actually slashes your breast-cancer risk? Redbook went to some of the...
Source: HighBeam Research, Breast cancer patients often fare better with dense-dose chemotherapy...