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Early data suggest valproate-birth defect link. (Preliminary Findings from Registry).
SEATTLE -- Sodium valproate had the highest rate of birth defects of any of 12 antiepileptic drugs during the first 30 months of an Australian epilepsy/pregnancy registry.
A total of 132 epileptic patients were exposed to valproate during pregnancy. Eighteen (13.6%) of those patients gave birth to a child with a defect. There was only one defect reported in 33 births to epileptic women who were not on medication, for a rate of 3%, Dr. Terence J. O'Brien said in a poster presentation at the annual meeting of the American Epilepsy Society.
The numbers in the Australian registry are preliminary, but the investigators decided to release them "to let people make their own judgment," Dr. O'Brien of the University of Melbourne said in an interview Both the United States and Britain have registries also, hut investigators overseeing those registries have decided not to report their preliminary data.
But Dr. O'Brien said he has seen the figures in the U.S. and British ...
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Source: HighBeam Research, Early data suggest valproate-birth defect link. (Preliminary Findings...