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Investigational genetic screen may predict chemotherapy responders. (Ovarian Cancer).
BALTIMORE -- A genetic screen for two metabolic enzymes identified women with ovarian cancer who did not respond to treatment with paclitaxel in a preliminary study with 41 patients.
This is the first time that a genetic screen for metabolic enzymes has distinguished patients who respond to cancer chemotherapy drugs from patients who are unable to respond to the drugs, Dr. J. Fernando Arena said at the annual meeting of the American Society of Human Genetics.
If the genetic screen is further refined and validated, it has the potential to identify early on those ovarian cancer patients who won't respond to standard therapy, thereby avoiding a time-consuming course of ineffective treatment, Dr. Arena, said.
The standard, first-line regimen for chemotherapy of epithelial, ovarian cancer is a combination regimen of paclitaxel and carboplatin. About 65% of women respond to the regimen.
Applying the genetic screen to a group of 41 patients identified a group of non-responders, of whom 60% failed to respond to the regimen, and a group of responders, of whom 96% responded, said Dr. Arena, director of translational research at the Familial Ovarian/Breast Cancer Center of the University of Miami.
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- Genetic screening may flag those who respond to chemotherapy. (Ovarian Cancer).
- Magazine article from: Family Practice News Zoler, Mitchel L. January 15, 2003 700+ words
...BALTIMORE -- A genetic screen for two metabolic...women with ovarian cancer who did not...If the genetic screen is further...on those ovarian cancer patients...marker of ovarian cancer. The genetic screen used 112...
- Ovarian cancer, a silent killer for Indonesian women: Study.
- Newspaper article from: Jakarta Post August 9, 2000 700+ words
...may be at a high risk of developing ovarian cancer. Dr. Sjahrul Sjamsuddin, a gynecologist...said the doctor during a seminar on ovarian cancer. Only a very few realize that the...talcum powder and the development of ovarian cancer in women," he said. The doctor explained...
- Ovarian cancer strikes one in 68 women: Now experts agree on a set of symptoms...
- Newspaper article from: Tulsa World (Tulsa, OK) August 2, 2007 700+ words
...estimated 15,000 Americans die of ovarian cancer, where malignant cells are found in...organs, the ovaries. For a long time, ovarian cancer was called the "silent killer" because...poor. Almost 70 percent of women with ovarian cancer are not diagnosed until the disease...
- Ovarian cancer genomic tests not reducing deaths.
- Magazine article from: Diagnostic Update October 19, 2006 700+ words
Ovarian cancer genomic tests not reducing deaths...to diagnose and guide treatment of ovarian cancer are not shown to decrease the number...125 or BRCA1 and BRCA2 to diagnose ovarian cancer or identify women at risk. Among...
- Ovarian cancer.(Disease/Disorder overview)
- CareNotes August 1, 2006 700+ words
GENERAL INFORMATION: What is ovarian cancer? * Ovarian cancer is a tumor (lump) in one or both ovaries. Normally...in helping the body work correctly. What causes ovarian cancer? There is no known cause of ovarian cancer. The...
- Ovarian Cancer Does Have Early Warning Signs; Mayo Clinic and Olmsted Medical...
- News wire article from: Europe Intelligence Wire November 18, 2004 700+ words
...symptoms recorded in the medical records of ovarian cancer patients suggest ovarian cancer, long considered asymptomatic until late...urinary incontinence and abdominal pain. "Ovarian cancer is called 'the silent killer,'" says...
- Ovarian cancer: the search for an accurate screening technique: few cases of...
- Magazine article from: JAAPA-Journal of the American Academy of Physicians Assistants Anderson, Lindsay February 1, 2009 700+ words
Ovarian cancer is known to be an extremely aggressive...combined. (1) Estimates show that ovarian cancer can shorten a woman's life by an...1) CHALLENGES TO EARLY DETECTION Ovarian cancer is difficult to detect early in the...
- Ovarian cancer screening guidelines.(Clinical Guidelines For Family Physicians)
- Magazine article from: Family Practice News Skolnik, Neil Kenny, Christine January 15, 2005 700+ words
Ovarian cancer is the fifth leading cause of cancer...Unfortunately, the early stages of ovarian cancer are often asymptomatic, and up to...and potential harm associated with ovarian cancer screening (Ann. Fam. Med. 2004...
- Ovarian Cancer.
- News wire article from: This Day (Nigeria) November 19, 2006 700+ words
...one on each side of the uterus. Ovarian cancer occurs when normal ovarian cells begin...detection. The signs and symptoms of ovarian cancer are non-specific and may mimic many...distinguishing signs and symptoms of ovarian cancer from the other more common disorders...
- Ovarian Cancer ... the Women's Cancer Too Many Women Don't Know About; CIGNA...
- Press release article from: PR Newswire September 3, 2003 700+ words
...the women who will be diagnosed with ovarian cancer this year will not find out they have...five years from now. However, when ovarian cancer is detected early, 95 percent of women...startling statistics is the goal of the Ovarian Cancer National Alliance (OCNA), which...
Source: HighBeam Research, Investigational genetic screen may predict chemotherapy responders....