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Allograft may augment prolapse repair. (2-Year Follow-up of Seven Patients).

OB GYN News

| January 01, 2003 | Boschert, Sherry | COPYRIGHT 2003 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

SAN FRANCISCO--A 2-year follow-up study of seven patients found that dermal allografts used to augment prolapse repairs integrated well with the patients' tissue and showed no signs of rejection.

Many gynecologic surgeons have begun using various implant materials to reinforce anterior and posterior colporrhaphies, which normally have a 16%-30% failure rate. Although the qualifies of the implants before insertion are well known, much less is understood about their disposition once placed in the vagina, Dr. Elizabeth Graul said at the annual meeting of the American Urogynecologic Association.

She and her associates took small vaginal biopsies of the implant from seven patients under local anesthesia 22-26 months after they underwent anterior or posterior colporrhaphies (or both) augmented with DuraDerm, which is distributed by C.R. Bard Inc. In the study which was sponsored by the company a single pathologist evaluated multiple specimens of the implant from each patient.

Subjectively, the implant appeared to be completely incorporated into the patient's own fibromuscular layer and was not identifiable as a separate layer. It looked like a thick, firm tissue, said Dr. Graul of Salt Lake City.

On histology fibrovascular tissue with ...

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