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INDIANAPOLIS -- A key concept in dealing with women with recurrent vaginitis is to treat until they are asymptomatic and then suppress with intermittent antimicrobial therapy, according to Dr. David Soper, a vaginitis expert.
"They need to recognize this is not a cure. At this point there is no cure for these people. This is just control of their symptoms," he said at the annual meeting of District V of the American College of Obstetricians and Gynecologists.
Recurrent bacterial vaginosis (BV) can be characterized by the patient's inability to recolonize herself sufficiently with protective vaginal lactobacilli, said Dr. Soper, professor of obstetrics, gynecology, and infectious diseases at the Medical University of South Carolina, Charleston.
"Not everyone with .BV is totally deficient in these bacteria--a substantial proportion of these patients do have lactobacilli--they just have low concentrations. But many of these patients, if not most of them, cannot regrow their lactobacilli, and these are the patients who are going to be at risk for recurrence," he said in an interview.
Patients in this category should be given suppressive therapy aimed at reducing the risk of recurrence and keeping them in an asymptomatic state. Dr. Soper suggested that most patients will remain asympromatic whenput on this regimen: metronidazole gel (0.75%, for 10 days), followed by twice weekly applications for 3 months.
One study showed that this regimen kept 83% of patients symptom free, compared with 33% who were symptom free on placebo. "You are not interested in these recurrent patients normalizing their vaginal flora under the microscope because this is not going to happen until they become recolonized with ...