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US, blood test flag Down syndrome. (93% First-Trimester Detection Rate).
NEW YORK--First-trimester screening using a combination of dried blood biochemistries and ultrasound examination of fetal nuchal translucency detected 93% of Down syndrome cases with a false-positive rate of 5% in a prospective study of 14,779 pregnancies.
A simple prick of the finger to measure serum levels of pregnancy-associated plasma protein (PAPP-A) and the [beta]-subunit of huma"" "" ""adotropin [beta]-HCG) can be combined with an ultrasound exam to effectively screen for Down syndrome or trisomy 18 in women of all ages, David A. Krantz reported during the 12th World Congress on Ultrasound in Obstetrics and Gynecology.
The ongoing study analyzed outcomes data available for 38% of 39,220 patients screened since 1995 using the combination protocol during weeks 10-13 of gestation.
Most of the women were screened in week 11 or 12, said Mr. Krantz, director of biostatistics at NTD Laboratories, Huntington Station, N.Y., which provides prenatal screening and testing to clinicians.
This a good first-trimester screen in women younger than 35 years of age, who can be reassured about their low risk if they get a negative result, Mr. Krantz said.
Older women who initially refuse an invasive diagnostic test such as amniocentesis or chorionic villus sampling may want to reconsider if they get a positive screening result on this first-trimester test.
If screening takes place at 11 weeks' gestation, women with a positive result can get an invasive diagnostic test and reach a diagnosis by the end of the first trimester, providing more time to consider management options and allowing earlier terminations for those who choose them.
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Source: HighBeam Research, US, blood test flag Down syndrome. (93% First-Trimester Detection...