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Misoprostol works as well as [PGF.sub.2[alpha]] for abortion. (Second-Trimester Pregnancies).
BALTIMORE -- Intravaginal misoprostol was as effective for ending second-trimester pregnancies as intraamniotic prostaglandin [F.sub.2[alpha]] in a controlled study with 217 women.
Although intraamniotic prostaglandin [F.sub.2[alpha]] ([PGF.sub.2[alpha]]) has been the standard method for medically induced, second-trimester pregnancy termination, intravaginal infusion of misoprostol has been increasingly used despite little evidence from head-to-head comparisons of the two methods. The results of this study show that intravaginal misoprostol is as effective as the alternative while causing less vomiting, Dr. Hani A. Akoury said while presenting a poster at the annual meeting of the American Society of Human Genetics.
Misoprostol is indicated solely for the prevention of gastric ulcers associated with the use of nonsteroidal anti-inflammatory drugs.
The study involved 217 women at week 15-24 of pregnancy at three university teaching hospitals in Toronto. They were randomized to three treatment groups: Women in one group received an intraamniotic infusion of 40 mg [PGF.sub.2[alpha]] followed 4 hours later by a continuous infusion of oxytocin for 24 hours or until labor began. The women in the second group received 400 [micro]g misoprostol as an intravaginal infusion every 4 ...
- Intravaginal misoprostol effective in evacuation. (Failed First-Trimester...
- Magazine article from: OB GYN News Walsh, Nancy December 1, 2002 700+ words
...surgery as well as the uncertainties of expectant management, he said. But reported evacuation rates with intravaginal misoprostol have ranged from 13% to 96%. "This wide range in evacuation rates may be due in part to variability in...
- Clostridium sordellii toxic shock syndrome after medical abortion with...
- Newspaper article from: Morbidity and Mortality Weekly Report July 29, 2005 700+ words
...abortions with Mifeprex[R] (mifepristone, formerly RU-486; Danco Laboratories, New York, New York) and intravaginal misoprostol (1). Two of these deaths occurred in 2003, one in 2004, and one in 2005. Two of these U.S. cases...
- New endometritis study results reported from D.M. Aronoff et al.(Report)
- Magazine article from: Women's Health Weekly October 2, 2008 700+ words
...Clinical C. sordelli infections were associated with intravaginal misoprostol administration, suggesting that high misoprostol concentrations...bacterial clearance in vivo. Misoprostol also reduced TNF-alpha production within the uterus during infection. The intrauterine...
- Parity, initial dilatation predict misoprostol success: older gestational age...
- Magazine article from: OB GYN News Bates, Betsy December 1, 2001 700+ words
...1,373 patients who received intravaginal misoprostol, primarily within six large...trial received 50 [micro]g of intravaginal misoprostol at 3-hour intervals for a maximum...had a successful induction with intravaginal misoprostol, compared with 63% of parous...
- Low-Dose Oral and Vaginal Misoprostol for Cervical Ripening and Labor Induction.
- Magazine article from: OB/GYN Clinical Alert August 1, 1999 700+ words
...effective than a 25-mcg dose of intravaginal misoprostol given every four hours for cervical...oral misoprostol or 25 mcg of intravaginal misoprostol every four hours. At enrollment...signifi- cantly less effective than intravaginal misoprostol for ripening the cervix and inducing...
- Low-Dose Oral and Vaginal Misoprostol for Cervical Ripening and Labor Inducti.
- Newspaper article from: Family Practice Alert August 1, 1999 700+ words
...effective than a 25-mcg dose of intravaginal misoprostol given every four hours for cervical...oral misoprostol or 25 mcg of intravaginal misoprostol every four hours. At enrollment...signifi- cantly less effective than intravaginal misoprostol for ripening the cervix and inducing...
- Study of 2,200 elective inductions: tips on labor induction using oral...
- Magazine article from: OB GYN News Jancin, Bruce April 1, 2004 700+ words
...by the Geisinger Health System. Although intravaginal misoprostol for labor induction has its devotees, Dr...In contrast, peak levels are lower with intravaginal misoprostol and remain elevated for 6 hours or more...
- Recent studies by K.S. Krithika and co-authors add new data to obstetrics...
- Magazine article from: Women's Health Weekly August 21, 2008 700+ words
...out to compare the efficacy and safety of intravaginal Misoprostol with intracervical dinoprostone gel for...trial to compare safety and efficacy of intravaginal Misoprostol with intracervical Cerviprime for induction...
Source: HighBeam Research, Misoprostol works as well as [PGF.sub.2[alpha]] for abortion....