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Karyotype after second first-trimester loss. (Rule out Nongenetic Causes).
BALTIMORE -- Get a chromosomal karyotype for every first-trimester spontaneous abortion if the mother has had at least one prior pregnancy loss, Ahigail L. Byrnes said while presenting a poster at the annual meeting of the American Society for Human Genetics.
Karyotyping can identify first-trimester, spontaneous abortions that probably had a genetic cause, thereby precluding more extensive and possibly unnecessary tests for recurrent pregnancy loss, said Ms. Byrnes, a genetic counselor at Magee-Womens Hospital in Pittsburgh.
Currently, karyotyping is not routinely done at all hospitals when a woman has her second first-trimester, spontaneous abortion, she told this newspaper.
"If an abnormal karyotype can rule out other causes of pregnancy loss and eliminate the need for further testing, it should be cost effective," she said. A conventional karyotype costs about $600. The prevalence of chromosomal abnormalities in pregnancy losses was determined for 489 pregnant women who had a spontaneous ...
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Source: HighBeam Research, Karyotype after second first-trimester loss. (Rule out Nongenetic...