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Fewer shunts after fetal spina bifida surgery. (Results of 50 Cases at One Center).
BALTIMORE -- In utero repair of myelomeningocele has now been done on more than 50 fetuses by surgeons at Children's Hospital of Philadelphia.
Among the first 50 cases, 40% required treatment with a ventriculoperitoneal shunt after they were born, compared with an historic 90% rate among infants born with spina bifida who did not undergo an in utero repair, Dr. N. Scott Adzick said at the annual meeting of the American Society of Human Genetics.
Leg function was better than expected in 66% of the neonates who had undergone fetal surgery Three of the first 50 fetuses died.
Based on these promising, single-center results, a randomized, controlled trial of fetal myelomeningocele repair is slated to start this month at three U.S. sites, with a projected enrollment of 200 children. The study is designed to determine the need for a shunt in the first year of life, which means that results from the study should be available in about 3 years. The study will include fetuses with a myelomeningocele at T1-S1 and Arnold-Chiari hindbrain herniation that is diagnosed and treated at a gestational age of 19-25 weeks.
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Source: HighBeam Research, Fewer shunts after fetal spina bifida surgery. (Results of 50 Cases...