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New data on ICSI called 'reassuring'. (More Follow-Up Needed).

OB GYN News

| December 01, 2002 | Walsh, Nancy | COPYRIGHT 2002 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

SEATTLE -- Concerns about genetic and developmental abnormalities among children conceived through assisted reproductive technology continue, although they have not been borne out by two new studies.

"Many of the developmental problems in ART children are because of multiple births," Dr. Jane Squires said at the annual meeting of the American Society for Reproductive Medicine.

But other concerns do exist, particularly for intracytoplasmic sperm injection (ICSI). "There's much more manipulation with ICSI than with traditional in vitro fertilization [IVF]. And there's no natural selection happening," said Dr. Squires of the University of Oregon, Eugene.

"There is reason to believe there might be more problems with these kids," she added.

But in a prospective study conducted by Dr. Squires and her associates among 110 children conceived through LVF, 16% were found to be "at risk" on measures of general developmental concerns at 3 years, meaning they showed early signs of developmental abnormalities, reported study investigator Queenie V. Neri, a research fellow at the Center for Reproductive Medicine and Infertility, Cornell University New York.

Among 229 conceived through ICSI, 14% were classified as at risk, Ms. Neri said during a press briefing at the meeting.

By comparison, a control rate of 10% of children conceived naturally could be expected to be at risk for developmental problems at this age, Dr. Squires said. The researchers called these data "reassuring."

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