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Estrogen still an option for osteoporosis treatment in selected women, expert says. (Breast Cancer Risk at Issue).
SAN ANTONIO -- Estrogen is not finished as a treatment for osteopenia or osteoporosis in postmenopausal women, despite the dramatic results from the Women's Health Initiative study, according to Dr. Susan L. Greenspan.
Hormone replacement therapy (HRT), in the form of either unopposed estrogen or estrogen plus a progestin, is an option for selected women, she said at the annual meeting of the American Society for Bone and Mineral Research.
The results from a recent randomized, controlled study with 373 women showed that combined treatment with HRT and alendronate (Fosamax) was more effective than either agent alone for improving bone mineral density in older postmenopausal women, reported Dr. Greenspan, who is on the speakers' bureau for Merck, which markets Fosamax. Dr. Greenspan said she does not receive funding from companies that manufacture estrogen products.
Other experts do not agree that HRT is suitable for even a select population of women at high risk for osteoporosis. Results from the Women's Health Initiative (WHI) study clearly showed that estrogen reduces a woman's fracture risk, but it's not now possible to dearly sort out the breast cancer risk, said Dr. John A. Robbins, a principal investigator in the WHI study and a professor of medicine at the University of California, Davis.
"Even for women with clear osteoporosis, I would just treat them with a bisphosphonate and not with estrogen. Why take the risk of using estrogen?" said Dr. Robbins, who said he has no financial ties to companies that market bisphosphonates.
Recent results from the Women's Health Initiative study showed that the use of estrogen plus progestin was associated with an unacceptably high risk of breast cancer, stroke, and pulmonary embolism. But these findings were ...
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Source: HighBeam Research, Estrogen still an option for osteoporosis treatment in selected...