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Long-term combined HRT may raise leiomyoma risk. (Patients with Low BMI).
CHICAGO -- Long-term use of combined hormone replacement therapy was associated with a 70% increased risk of uterine leiomyoma in peri- and postmenopausal patients in a recent case-control study.
The study--said to be the first to look specifically at the association between leiomyoma formation and prior HRT use--involved 256 women with a confirmed first case of leiomyoma and 276 control patients in the same age range who had no previous diagnosis of leiomyoma. Long-term use of HRT was defined as at least 5 years, Dr. Susan D. Reed reported at the annual meeting of the North American Menopause Society.
The association between use of HRT and leiomyoma development was restricted to those with lower adiposity as measured by body mass index, noted Dr. Reed of the University of Washington, Seattle.
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