Fearless forecast.

Denver at San Diego. When these teams met in Week 5, the Broncos' run defense was up to the task against LaDainian Tomlinson, who was held to 48 yards rushing in Denver's win. The key for Denver to take the rematch is hitting on a few big passes early, opening up room for its own running game and making San Diego play from behind. When the Chargers turn away from Tomlinson and rely more on the pass, it plays fight into the hands of the Broncos' athletic linebackers and aggressive defensive backs. Pick: Broncos 20, Chargers 13.

Tampa Bay at New Orleans. The Bucs' top-ranked pass defense faces a tough challenge against the Saints' electric offense on the Superdome's fast track. The hosts will have success moving the ball if they get Tampa Bay out of its base package. To do this, the Saints have to both throw and run ...