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Higher VEGF levels tied to ectopic pregnancy. (Vascular Endothelial Growth Factor).
ORLANDO, FLA. -- Serum levels of vascular endothelial growth factor are significantly higher in women with ectopic pregnancies, compared with those with arrested intrauterine pregnancies, Dr. Togas Tulandi reported.
Moreover, this marker may be able to help physicians make an earlier distinction between these two conditions and identify appropriate treatments sooner, he commented at the annual meeting of the American Society for Reproductive Medicine.
"An early diagnosis of ectopic pregnancy will allow a conservative treatment, including medical treatment with methotrexate. And more importantly, the earlier the medical treatment is given, the higher its success rate," said Dr. Tulandi, professor of obstetrics and gynecology and director of the division of reproductive endocrinology and infertility at McGill University in Montreal.
In the study, asymptomatic women with an early diagnosis of pregnancy underwent blood sampling at 5 weeks' gestation for serum vascular endothelial growth factor (VEGF) measurements. The diagnosis of ectopic pregnancy, arrested intrauterine pregnancy, or viable pregnancy was established approximately 1-2 weeks later.
Looking at 15 women from each of the three diagnostic categories, Dr. Tulandi found that levels of VEGF varied significantly from those with ectopic pregnancies (306.1 pg/mL), arrested intrauterine pregnancies (69.7 pg/mL), and normal intrauterine pregnancies (27 pg/mL).
"This could be due to increased production of VEGF originating from the hypoxic condition of the tube and/or from altered production of VEGF binding protein in abnormal pregnancies," he suggested.
When a serum VEGF level of 200 pg/mL was used as the upper cutoff for a normal intrauterine pregnancy, levels above that could be used to distinguish an ectopic pregnancy from a normal pregnancy with a ...
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Source: HighBeam Research, Higher VEGF levels tied to ectopic pregnancy. (Vascular Endothelial...