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Proton pump inhibitor safety. (GI Disorders).
Patients have used proton pump inhibitors to stop gastric acid production for up to 17 years without increasing their risk of developing gastric carcinoids.
This finding is "reassuring for patients regularly using a proton pump inhibitor to treat gastroesophageal reflux or Barrett's esophagus," Dr. Fathia Gibril said in a poster presentation at the annual Digestive Disease Week.
When omeprazole (Prilosec) came onto the market in the mid-1980s as the first proton pump inhibitor approved for use in the United States, many experts were concerned that long-term, chronic use might raise a patient's risk of gastric carcinoids. This cancer appeared at an accelerated rate in some of the animal models that had been used to test the safety of long, uninterrupted use.
Dr. Gibril and her associates reviewed the experience of 143 patients who have undergone continuous treatment with omeprazole for ...
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- Magazine article from: Southern Medical Journal Darabi, Kamran August 1, 2005 700+ words
...the discontinuation of pantoprazole, suggesting proton-pump-inhibitor-induced hepatitis. In cases of hepatitis of unclear...should always be reviewed as possible culprits. Proton-pump-inhibitors (PPIs) are generally recognized as...
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...has developed multilayer proton pump inhibitor tablets. The patent has...Multilayer tablets of a proton pump inhibitor essentially bioequivalent...multiple unit pellets of the proton pump inhibitor are provided. Also provided...
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- Magazine article from: Family Practice News BAKER, BARBARA October 15, 1999 700+ words
...VANCOUVER, B.C. -- A 1-to 2-week trial of a proton pump inhibitor may be the best way to make the diagnosis of gastroesophageal...gastroenterology and endoscopy. A therapeutic trial with a proton pump inhibitor (PPI) has good diagnostic accuracy, is cost effective...
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- News wire article from: Ascribe Higher Education News Service April 8, 2009 700+ words
...benefit from using so-called proton pump inhibitors in the absence of the...doses of the most commonly used proton pump inhibitor -- 80 milligrams of esomeprazole...The bottom line here is that proton pump inhibitors do not improve control...
Source: HighBeam Research, Proton pump inhibitor safety. (GI Disorders).