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GnRH agonists may offer novel option for interstitial cystitis. (Cyclic Irritable Bladder Symptoms).
ASHLAND, ORE. -- Hormonal manipulation may prove to provide relief for women with chronic, cyclic irritable bladder symptoms, results of a University of Washington pilot study suggested.
Eight of nine patients prescribed GnRH agonists for 6 months "markedly improved," even though they had failed numerous other therapies for long-standing pain associated with interstitial cystitis, said Dr. Gretchen Lentz of the university in Seattle.
Two patients relapsed once the trial was completed, hut both were cured when one underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy and the other, a bilateral salpingo-oophorectomy Dr. Lentz reported at the annual meeting of the Pacific Coast Obstetrical and Gynecological Society.
The sole patient who failed the trial of GnRH agonists also failed to improve after a total abdominal hysterectomy and bilateral salpingo-oophorectomy the investigator said.
In another arm of the study OCs were prescribed to six patients who similarly suffered chronic, cyclic interstitial cystitis symptoms, and five improved.
Dr. Lentz called the results "interesting," and said hormone manipulation for interstitial cystitis "certainly merits more study" especially in light of published studies documenting sustained improvement of irritable bowel syndrome symptoms in patients given GnRH agonists.
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Source: HighBeam Research, GnRH agonists may offer novel option for interstitial cystitis....