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Smokers seem to have better clinical outcomes following an acute MI than nonsmokers do. Now cardiovascular epidemiologists have an explanation for this so-called smokers' paradox.
New data suggest a twofold explanation: Compared with nonsmokers, smokers are relatively younger at the time of their first MI and have a lower incidence of anterior MIs, which tend to be larger and more severe infarctions, Sarah R. Kermgard reported at the annual meeting of the American College of Cardiology.
She reviewed data from four of the Thrombolysis in Myocardial Infarction trials involving a total of 1,179 active smokers and 1,232 nonsmokers with acute MI. Univariate analysis demonstrated the smokers' paradox at work: 30-day mortality was 6.22% in nonsmokers, compared with 2.57% among smokers. The smokers ...
Source: HighBeam Research, The smokers' MI paradox. (Cardiology).