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Commercially available genetic testing is now the screening method of choice for hereditary colorectal cancer, Dr. Francis M. Giardiello said at the annual meeting of the American Society of Colon and Rectal Surgeons.
Before these tests were available, atrisk family members had to undergo frequent endoscopic evaluations for decades. Now, individuals who have negative results on genetic testing can be safely spared frequent procedures, said Dr. Giardiello of the Johns Hopkins University; Baltimore.
Most people at risk for familial colorectal cancer don't have one of the few well defined disorders for which genetic testing is available, Dr. Giardiello noted. Close to 20% of all cases of colorectal cancer cluster in families, and the disorders for which genetic tests are available account for only about 3% of all colorectal cancer in the United States. Genetic testing is commercially available for:
* Familial adenomatous polyposis (FAP). The screening test of choice is an adenomatous polyposis coli (APC) gene test, which should be done at age 10-12 years, following formal pretest genetic counseling ...