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Antidepressants for generalized anxiety disorder.(Cochrane For Clinicians: Putting Evidence Into Practice)

Publication: American Family Physician

Publication Date: 01-NOV-03

Author: Flynn, Cheryl A. ; Chen, Y.C. Christine
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COPYRIGHT 2003 American Academy of Family Physicians

The Cochrane Abstract below is a summary of a review from the Cochrane Library. It is accompanied by an interpretation that will help clinicians put evidence into practice. Cheryl A. Flynn, M.D., M.S., and Y.C. Christine Chen, M.P.H., present a clinical scenario and question based on the Cochrane Abstract, along with the evidence-based answer and a full critique of the abstract.

This clinical content conforms to AAFP criteria for evidence-based continuing medical education (EB CME). EB CME is clinical content presented with practice recommendations supported by evidence that has been systematically reviewed by an AAFP-approved source. The practice recommendations in this activity are available at http://www.cochrane.org/cochrane/revabstr/AB003592.htm

Clinical Scenario

A 40-year-old man is in counseling for generalized anxiety disorder (GAD). He asks about pharmacotherapeutic treatment options, expressing a desire to avoid addictive medications.

Clinical Question

Are antidepressants an effective and acceptable treatment for GAD?

Evidence-Based Answer

As a group, antidepressants are an effective short-term treatment for GAD. Compared with placebo, about five to six patients must be treated to get...

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