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DENVER -- Weight-loss medications should never be prescribed for obese patients without also enrolling them in a program with behavioral modification and a dietary intervention, Dr. Samuel Klein said at an international conference of the Academy for Eating Disorders.
This triple-pronged approach is essential. Studies clearly show that the long-term weight loss achieved with orlistat or sibutramine alone--the only two drugs approved for long-term therapy--is rather modest. The cost and side effects of the medication remain the same regardless of whether the regimen also includes behavioral and dietary interventions, but the long-term weight loss is markedly enhanced with multimodal therapy.
In other words, although pharmacotherapy can be useful, the cornerstone of obesity treatment remains lifestyle changes, said Dr. Klein, the William H. Danforth Professor of Medicine and Nutritional Science at Washington University, St. Louis.
He provided these…