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Failed IVF may be due to defective uterine receptivity, inflammation. (Treat with Lupron, Laser Surgery).
ASHEVILLE, NC. -- Ongoing research on the process of implantation suggests that those women who have the most difficulty becoming pregnant may have defects in uterine receptivity, Dr. Bruce A. Lessey said at the annual Southern Obstetric and Gynecologic Seminar.
Among women undergoing in vitro fertilization (IVF), there may be 50%-60% who become pregnant on the first try After a second attempt, the pregnancy rate may drop to about 40%, and the rate continues to diminish with each attempt. Women who fail to get pregnant on the fourth attempt may well have receptivity defects, said Dr. Lessey, professor of medicine at the University of North Carolina at Chapel Hill.
Inflammation due to hydrosalpinx or endometriosis may play a part in the lack of uterine receptivity.
The process of uterine receptivity is complex, but expression of certain biomarkers, including integrins such as [[beta].sub.3]. appears to play a role in successful implantation. Lack of these biomarkers is associated with decreased pregnancy rates; in women with endometriosis who express [[beta].sub.3], the pregnancy rate is about 70%, but those who do not express [[beta].sub.3] get pregnancy very rarely and only with IVF, Dr. Lessey said.
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Source: HighBeam Research, Failed IVF may be due to defective uterine receptivity, inflammation....