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MRI under investigation for use in diagnosis of fetal lung anomalies. (Signal Intensity Flags Fluid Content).
CHICAGO -- Researchers are homing in on how to best apply magnetic resonance imaging to identify fetuses with lung development abnormalities such as pulmonary hypoplasia, but it's not ready for prime time yet.
Still, "we believe that [in the future] MRI will play an increasing role in the diagnosis of fetal lung abnormalities," Dr. Thomas Keller said at the annual meeting of the Radiological Society of North America.
The idea is that signal intensity is an indication of fluid Content in the lung. And since immature lungs with no alveoli have little fluid, "in our opinion ... it can be used as a measure of lung maturity," he explained in an interview.
In a study aimed at establishing normative values for magnetic resonance signal intensity and volume estimations, Dr. Keller and colleagues at the University Hospital of Zurich (Switzerland) compared values among 35 uncomplicated pregnancies with those of 7 pregnancies involving fetuses with lung pathologies. All patients underwent single shot fast spin echo (SSFSE) imaging between 22 and 42 weeks' gestation.
As expected, preliminary data indicated that the absolute lung volume increased with gestational age, although there was a decrease in lung volume relative to total fetal body volume toward the end of pregnancy. The relative lung volume in normal pregnancies varied from 1.6% to 5% of total fetal body volume.
Overall, ...
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Source: HighBeam Research, MRI under investigation for use in diagnosis of fetal lung anomalies....