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Missing fetal nasal bone refines trisomy 21 Dx. (Ultrasound Screening at 11-14 Weeks).
Ultrasound screening for the absence of a fetal nasal bone at 11-14 weeks' gestation is a new technique that offers promise for further refining the prenatal diagnosis of trisomy 21, according to Dr. Simona Cicero of King's College Hospital Medical School, London, and her associates.
The researchers performed ultrasound evaluation on 701 fetuses who were considered to be at risk for the chromosomal abnormality because of advanced maternal age and a previous finding of nuchal translucency
Among 59 fetuses later determined by chorionic villus sampling and fetal karyotyping to have trisomy 21, the nasal bone was noted to be absent on ultrasound in 43 (73%). In comparison, among the 603 normal-karyotype fetuses, the nasal bone was absent in only 3 (0.5%).
Screening for trisomy 21 by ...
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Source: HighBeam Research, Missing fetal nasal bone refines trisomy 21 Dx. (Ultrasound Screening...