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New Research Explores Definition, Incidence and Treatment of Mild Cognitive Impairment (MCI); For First Time, A Current Alzheimer Drug May Delay Transition from MCI to Alzheimer's.

The America's Intelligence Wire

| July 18, 2004 | COPYRIGHT 2003 Financial Times Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

(From US Newswire)

To: National Desk, Health Reporter

Contact: Niles Frantz of the Alzheimer's Association, 312-286-0295 (cell) or niles.frantz@alz.org, Alzheimer's Association Media Line: 312-335-4078 or media@alz.org, International Conference on Alzheimer's Disease and Related Disorders press room, July 18-22: 215-418-2054

PHILADELPHIA, July 18 /U.S. Newswire/ -- Individuals with mild cognitive impairment (MCI) who took the Alzheimer drug donepezil had a reduced risk of progressing to Alzheimer's disease compared to those who took placebo, according to preliminary data reported today at the 9th International Conference on Alzheimer's Disease and Related Disorders (ICAD), presented by the Alzheimer's Association.

The risk reduction appeared to be temporary, lasting for only the first 18 months of a three-year trial. When individuals in the study did progress to Alzheimer's, those taking donepezil developed the disorder an average of six months later than those taking the placebo.

"This is the first study to demonstrate a positive treatment effect on progression to Alzheimer's disease from MCI," said Ronald Petersen, M.D., Ph.D., a principal investigator in the study, which was funded by the National Institute on Aging (NIA). "It looks like the drug had a modest, time-limited effect.…

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