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Both lamotrigine, lithium delay relapse of bipolar disorder. (Two International, Open-Label Studies).

Clinical Psychiatry News

| October 01, 2002 | Boschert, Sherry | COPYRIGHT 2009 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

YOKOHAMA, JAPAN -- Two of the longest studies of maintenance therapy for bipolar disorder found that both lithium and the antiepileptic drug lamotrigine delayed relapse, with lithium predominantly preventing manic episodes and lamotrigine predominantly preventing depression, Dr. Joseph R. Calabrese reported at the 12th World Congress of Psychiatry.

Two international, open-label studies treated 1,315 symptomatic bipolar patients with lamotrigine and concurrent psychotropics. The 638 patients stabilized in 8-16 weeks of treatment then were randomized in a double-blind fashion to maintenance therapy with lithium, lamotrigine, or placebo for 18 months (76 weeks), with…

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