Landmark PROactive Trial Investigates Effect of ACTOS(R) (pioglitazone HCl) on Cardiovascular Disease Progression; More than 5,000 patients with type 2 diabetes studied.

LINCOLNSHIRE, Ill., June 28 /PRNewswire/ -- In the July 2004 issue of Diabetes Care, researchers published the study design and baseline characteristics of patients enrolled in the landmark PROspective PioglitAzone Clinical Trial In MacroVascular Events Study (PROactive). PROactive is a European clinical trial assessing the effects of ACTOS(R) (pioglitazone HCl) on mortality and morbidity associated with cardiovascular disease progression in patients with type 2 diabetes. The study has enrolled 5,238 patients in 19 countries who have experienced one or more cardiovascular events such as a heart attack, coronary artery bypass surgery or stroke.

"Major studies have shown that sustained improvements in glycemic control significantly reduce the risk of some microvascular complications, but data remain inconclusive that intervention with conventional glucose-lowering agents is successful in modifying macrovascular disease," said John Dormandy, M.D., professor of Vascular Sciences at St. George's Hospital, London, and chairman of the PROactive study steering committee. "Recent studies have shown…