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Study confirms need for adrenal-antibody test in women with premature ovarian failure. (3%-4% Incidence of Adrenal Insufficiency).
An adrenal-antibody test is the best way to screen for adrenal insufficiency in women with premature ovarian failure.
About 3%-4% of women with premature ovarian failure (POF) have adrenal insufficiency and need adrenal-hormone replacement therapy, based on a study of 123 women with POF, Dr. Lawrence M. Nelson and his associates reported (Hum. Reprod. 17[8]:2096-2100, 2002). Adrenal insufficiency is about 300 times more common in women with POF than in the general population.
"All women diagnosed with POF should have an adrenal antibody test to screen for adrenal insufficiency," Dr. Nelson said in an interview.
The test is widely available and costs S60-$100. Autoimmune adrenal insufficiency is potentially fatal if it is undiagnosed or untreated. By age 40, about 1% of women develop POF.
It remains unclear why women with POF have a high prevalence of adrenal insufficiency. In the past, the two disorders were viewed as completely independent, but the current working hypothesis of Dr. Nelson and his associates is that a single autoimmune process results in dysfunction of both the ovaries ...
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