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Chronic use of depot medroxyprogesterone acetate may have an adverse effect on cardiovascular health, a small, nonrandomized study suggests.
The widely used, long-acting contraceptive sold as Depo-Provera and given as a 150-mg injection every 12 weeks inhibits ovarian follicle proliferation. This causes anovulation and decreased circulating estrogen, which could lead to reduced arterial function and increased risk of cardiovascular disease, Morten B. Sorenson, Ph.D., of Royal Brompton Hospital, London, and his colleagues reported (Circulation; available at http://circ.ahajournals.org/rapidaccess.shtml; published online Sept. 3, 2002).
While the investigators concluded that the "prevailing recommendation to use [Depo-Provera] in women with cardiovascular disease" should be further evaluated, Pharmacia, the drug's maker, is emphasizing its "well-proven" safety profile.
"There is no increased risk of cardiovascular disease noted in large-scale clinical or epidemiological trials with Depo-Provera," Dr. Joel Krasnow, medical director of women's healthcare for Pharmacia, Peapack, N.J., said in a statement issued-by the ...