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Two new studies suggest that HRT's risks may outweigh its benefits. (More Support for WHI Results).
Health officials preparing for an upcoming public meeting on the "state of the science" of replacement therapy now have more to go on.
Two new studies support recent findings that hormone replacement therapy (HRT) does not prevent cardiovascular disease, and that the risks of the therapy may outweigh its benefits. Both studies were conducted on behalf of the U.S. Preventive Services Task Force to aid in development of updated HRT recommendations expected out this fall, according to the Agency for Healthcare Research and Quality which sponsors the task force and funded the studies.
In the first study, which drew upon previously published data, HRT use was not associated with a significantly increased risk of death due to cardiovascular disease (summary relative risk of 0.75) or coronary artery disease (summary relative risk of 0.74), but it was associated with increased incidence of cardiovascular disease (summary relative risk of 1.28), Dr. Linda L. Humphries of the Oregon Health & Science University, Portland, and her colleagues reported.
The investigators analyzed 20 observational studies, 1 randomized controlled trial, and 1 metaanalysis that looked at outcomes other than cardiovascular disease. All included studies that were rated as fair or good in quality according to U.S. Preventive Services Task Force criteria (Ann. Intern. Med. 137[4]:273-84, 2002).
In the second newly published study, which involved a systematic literature review and metaanalysis of data on various outcomes, HRT was shown to have some benefit for preventing osteoporosis and colorectal cancer. However, it also increased the risk of coronary heart disease (CHD), stroke, thromboembolism, cholecystitis, and--in those who used HRT for more than 5 ...
- Croatia: HRT Programmes Council sets up task force.
- Newspaper article from: BBC Monitoring International Reports January 20, 2006 700+ words
...of the national broadcaster HRT on Thursday [19 January] set up a three-member task force to analyse the Council's...work in line with the Law on HRT. At the end of last year...it had failed to warn the HRT director and the programmes...
- Two new studies back finding that HRT's risks may outweigh benefits....
- Magazine article from: Family Practice News Worcester, Sharon September 15, 2002 700+ words
...U.S. Preventive Services Task Force to aid in development of updated HRT recommendations that are expected...Quality which sponsors the task force and funded the studies. The...public meetings on the matter of HRT use, including one sponsored...
- Limit HRT use to symptom control. (Long-Term Combo Therapy Poses...
- Magazine article from: Family Practice News Mechcatie, Elizabeth August 1, 2002 700+ words
...the first year. Yet combination HRT "clearly works" for symptoms...Society, agreed that short-term HRT was still an option; he would feel...using short-term therapy. An AGOG task force on HRT that was formed in June is developing...
- Long-term use of combo HRT: risks outweigh benefits; experts say that...
- Magazine article from: OB GYN News Mechcatie, Elizabeth August 1, 2002 700+ words
...Rossouw said. If women opt to use HRT, they "should do so for a short...Society agreed that short-term use of HRT was still an option, but he said...is appropriate for them. An AGOG task force on HRT that was formed in June is developing...
- WHI researchers defend their findings on HRT: some workshop attendees criticize...
- Magazine article from: OB GYN News Moon, Mary Ann November 15, 2002 700+ words
...combined estrogen-progestin HRT should not be taken solely to...Health. But few women take HRT for those reasons alone. This...be generalized to different HRT formulations, dosages, and...U.S. Preventive Services Task Force (USPSTF) all concurred with...
- Data on ovarian Ca, HRT use called insufficient. (Literature Review).
- Magazine article from: OB GYN News Brunk, Doug April 15, 2003 700+ words
...hormone replacement therapy (HRT) and ovarian cancer for the United States Preventive Services Task Force to assist them in their assessment...potential harms and benefits of HRT. Dr. Mahotiere, who conducted...examined the association between HRT use and ovarian cancer. The...
- Evidence is insufficient to determine If HRT affects ovarian cancer risk....
- Magazine article from: Family Practice News Brunk, Doug April 15, 2003 700+ words
...hormone replacement therapy (HRT) and ovarian cancer. The review...U.S. Preventive Services Task Force in its assessment of the potential harms and benefits of HRT. Dr. Mahotiere, who conducted...examined the association between HRT use and ovarian cancer. She...
- ACOG issues state-of-the-art guide to HRT.
- Magazine article from: Managed Care Weekly October 18, 2004 700+ words
...Hormone Therapy" report, written by a task force of 21 national experts, "is an exhaustive...Isaac Schiff, MD, chair of the ACOG Task Force on Hormone Therapy. Among the findings...flashes. As for herbal remedies, the Task Force concludes: "Treatment with wild yam...
- Discussion on HRT pros, cons needed, expert says.
- Magazine article from: Managed Care Weekly May 24, 2004 700+ words
...noted Schiff, who chairs ACOG's Task Force on Hormone Therapy and heads the advisory...With this latest data, ACOG's Task Force on Hormone Therapy, which has been analyzing...for 2 years. We plan to publish the Task Force report in the fall [2004]," stated...
- Should HRT be replaced?
- News wire article from: Asia Africa Intelligence Wire August 16, 2002 700+ words
...statement summarizes the findings and gives some relevant statistics. Most important, perhaps, is this paragraph: "ACOG's Task Force, formed in June, will expedite its research review and deliberations in light of recent study findings on the effect of...
Source: HighBeam Research, Two new studies suggest that HRT's risks may outweigh its benefits....