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Congenital adrenal hyperplasia. (Dexamethasone Tx).
SAN FRANCISCO -- Prenatal treatment of congenital adrenal hyperplasia with dexamethasone effectively reduced virilization of the genitalia in female infants with few, mostly mild effects on the mothers, according to one of the largest series of such cases ever reported.
"All of the fetuses who were treated from the sixth or seventh week and were treated to term ... ended up with [genitalia rated as] Prader 1, which is normal, or Prader 2 at the most," Dr. Maria I. New said at the annual meeting of the Endocrine Society.
The case series presented by Dr. New, a professor of pediatrics at Cornell University, New York, included 576 pregnant women undergoing amniocentesis or chorionic villi sampling for prenatal diagnosis of congenital adrenal hyperplasia because of a family history of the disorder.
The women were seen at New York-Presbyterian hospital between 1978 and 2002.
There were 64 female infants with classic 21-hydroxylase deficiency. A total of 27 women started treatment before the ninth week of gestation, 24 either started treatment after the ninth week or were not compliant throughout pregnancy, and 13 were untreated.
Treatment was 20 ...
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Source: HighBeam Research, Congenital adrenal hyperplasia. (Dexamethasone Tx).