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Cerebral changes seen in twins without TTTS. (Discordant birth weights).
OSLO--A higher than expected rate of anomalies was found on neonatal cerebral ultrasounds in discordant birth-weight twins without twin-twin transfusion syndrome in a study presented at the 18th European Congress of Perinatal Medicine,
"We found several cerebral changes in both the transfusion syndrome babies and the non-transfusion syndrome babies, but the last group is not supposed to be [at] such a high risk," said Dr. Henrik Brun, consultant in pediatrics, the Children's Center, Ulevaal University Hospital Trust, Oslo. "You would expect the transfusion syndrome babies to be much more pathologic when it comes to the brain, so that was surprising."
Dr. Brun and colleagues retrospectively studied 50 sets of twins born at least 20% discordant by weight at a hospital in Oslo. In 1998, the hospital began routine, neonatal, cerebral ultrasound examinations in all birth-weight discordant twins. The 50 discordant twin sets represented 21% of the 238 total twin sets born there between 1998 and 2001.
The researchers studied the 36 sets of discordant twins with ultrasound findings in the first neonatal week to exclude other causes of pathology. In nine of these twin sets, cerebral ultrasound was performed in only one of the twins. The anomalies discovered on ultrasound included subependymal pseudocysts, ventriculomegaly, cystic periventricular leukomalacia, periventricular echodensities, hemorrhage, and lenticulostriate vasculopathy.
Eleven sets of twins were diagnosed with twin-twin transfusion syndrome (TTTS), which increases risk of cerebral abnormalities and death in the neonatal period.
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Source: HighBeam Research, Cerebral changes seen in twins without TTTS. (Discordant birth...