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Danazol may be linked to rise in ovarian cancer, small study finds. (Risk raised two-to threefold).
MIAMI BEACH--Danazol use may be associated with increased risk for ovarian cancer, the results of a small study suggest.
In the study, which included pooled data from two case-control studies, women who used danazol were nearly three times more likely to develop ovarian cancer than were those using leuprolide, Dr. Roberta B. Ness reported at the annual meeting of the Society of Gynecologic Oncologists.
Of 1,373 women with ovarian cancer, 195 also had endometriosis; of 1,980 control patients without ovarian cancer, 195 had endometriosis. Of the 195 ovarian cancer/endometriosis patients, 12 had used the synthetic androgen danazol to treat their endometriosis, and 8 had used the antiandrogenic gonadotropin-releasing hormone agonist Lupron; of the 195 controls, 5 had used danazol, and 7 had used leuprolide, said Dr. Ness of the University of Pittsburgh.
Previous studies have shown that women with endometriosis have up to a 50% greater risk of developing ovarian cancer than other women. In this study, women with endometriosis were 1.5-fold more likely to develop ovarian cancer. The use of danazol seems to further increase the risk of ovarian cancer in women with ...
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Source: HighBeam Research, Danazol may be linked to rise in ovarian cancer, small study finds....