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Placenta implicated in infantile hemangioma. (Insights Pave Way For Novel Therapies).
PARIS -- The placenta may play a key role in the pathogenesis of infantile hemangioma, Dr. Martin C. Mihm Jr. said at the 20th World Congress of Dermatology.
Dr. Mihm, together with Dr. Paula E. North of the University of Arkansas, Little Rock, and their colleagues, have discovered that infantile hemangiomas and human placental microvessels share a unique constellation of four tissue-specific antigens. Based upon this shared phenotype, the investigators have developed new hypotheses about the origin of infantile hemangiomas.
The four antigens that are highly expressed both by infantile hemangioma endothelium and placental chorionic villi are glucose transporter 1 along with Lewis Y, Fc-gammaRII, and merosin. This combination wasn't expressed by any other benign vascular lesions nor by nonvascular malignancies, normal skin, or brain, according to Dr. Mihm, director of the vascular birthmarks clinic at Massachusetts General Hospital, Boston.
One hypothesis is that the shared phenotype results from embolization of placental vascular cells to fetal tissue during gestation. This would explain the well-documented increased frequency of infantile hemangiomas following chorionic villus sampling to detect fetal anomalies.
As for the postnatal rapid growth of ...
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