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Metformin's benefit not limited to obese patients: increases ovulation, decreases testosterone. (Polycystic Ovary Syndrome).
SAN FRANCISCO -- Metformin significantly increases the frequency of ovulation and decreases circulating testosterone in women with polycystic ovary syndrome who are not obese and have normal indices of insulin sensitivity, Dr. Jean-Patrice Baillargeon said at the annual meeting of the Endocrine Society.
Previous studies have shown only that insulin-sensitizing drugs are useful in polycystic ovary syndrome (PCOS) patients generally; many of these patients are insulin resistant and/or overweight, said Dr. Baillargeon of the Medical College of Virginia, Richmond.
Moreover, the current study found that metformin treatment significantly reduced insulin levels, even though the study patients were not apparently insulin resistant. This finding suggests some insulin resistance in all women with PCOS, Dr. Baillargeon said.
In the study 100 women with PCOS who were not obese and had normal indices of insulin sensitivity were randomized to receive 6 months of treatment with either metformin, rosiglitazone, metformin plus rosiglitazone, or placebo.
The mean number of ovuladons over the 6 months--defined as a serum progesterone level above 4.0 ng/mL followed by menstrual bleeding--was 0.4 for the patients assigned to placebo, 3.3 for those on metformin, 2.4 for those on ...
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...treatment regimen of metformin can help reduce...with polycystic ovary syndrome, according to...with polycystic ovary syndrome (PCOS) and acne...adapted dose of metformin for 6 months...Month Results of Metformin Therapy for PCOS...with polycystic ovary syndrome. ...
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...significant for polycystic ovary syndrome (PCOS), which was diagnosed...You have heard of utilizing metformin as an initial treatment for...women with PCOS. You think metformin may be a good option because...research supports the use of metformin and how to use it in this...
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...Treatment with metformin appeared to cut the...women with polycystic ovary syndrome. The women together...they were treated with metformin; the incidence of...women with polycystic ovary syndrome (PCOS) who were not...were not treated with metformin but were managed at...
- Metformin with diet reduced cardiovascular risk in PCOS.(polycystic ovary...
- Magazine article from: Internal Medicine News Splete, Heidi June 1, 2005 700+ words
WASHINGTON -- Metformin combined with a reduced...women with polycystic ovary syndrome, Mofiz Haque, M...2005 meeting. The metformin-diet (MET-D...Research. Overall, metformin targeted to 2,500...women with polycystic ovary syndrome are obese, with unhealthy...
- Metformin Appears Effective in Teens With PCOS.(polycystic ovary...
- Magazine article from: Family Practice News JANCIN, BRUCE August 15, 2000 700+ words
TORONTO -- Metformin appears to be an effective...adolescents with polycystic ovary syndrome, Dr. Kenneth L. Jones...recent national study of metformin in type 2 diabetes, this...California, San Diego. Metformin recently received Food...
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...insulin sensitizers in women with polycystic ovary syndrome. Those drugs include metformin (Glucophage, Bristol-Myers Squibb...almost 90% of women with polycystic ovary syndrome who took metformin for a month ovulated spontaneously or...
