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Statin treatment leaves luteal cycles unchanged. (Four Months of Therapy).
ATLANTA -- Statins do not disrupt the luteal cycle in reproductive-age women, based on results from a controlled study with 86 women.
This confirmation is important since the newest guidelines for cholesterol testing and management call for treating at-risk patients regardless of their gender and age, Dr. Nanette F. Santoro said in a poster presentation at the annual meeting of the American College of Cardiology.
There had been some concern that statin therapy might affect steroid hormone biosynthesis and lead to menstrual cycle changes with long-term use. But the results showed no change in luteal cycles during 4 months of treatment, said Dr. Santoro, director of the division of reproductive endocrinology at the Albert Einstein College of Medicine in New York.
The results are especially relevant for women with polycystic ovary disease, who are most likely to need lipid-lowering therapy. "I'm reassured that a statin will not worsen their hormonal status," she told this newspaper.
The study enrolled women aged 25-41 who had a history of regular menstrual cycles and a serum level of low-density lipoprotein cholesterol of 130-250 ...
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Source: HighBeam Research, Statin treatment leaves luteal cycles unchanged. (Four Months of...