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SAN FRANCISCO -- In the not too distant future, physicians may be able to identify the patients with early-stage breast cancer who run the highest risk of developing invasive carcinoma and metastases, thanks to a staining test developed at the University of Michigan in Ann Arbor.
The test detects a protein called RhoC, which is produced by invasive, inflammatory breast cancer cells, as well as by certain tumors of the liver, pancreas, and skin. Women who have small breast tumors but high RhoC levels could be candidates for more aggressive early treatment, Dr. Celina Kleer said at the annual meeting of the American Association for Cancer Research.
RhoC is shorthand for RhoC-GTPase, an enzyme normally involved in muscle cell structure and motility. But in tumor cells that express it, RhoC confers the ability to detach and metastasize.
Using 184 breast tissue slides from 164 patients, Dr. Kleer and her colleagues tested a specially developed polyclonal ...
Source: HighBeam Research, Staining may indicate invasive breast cancer. (Investigational...