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LOS ANGELES -- The midtrimester amniocentesis-related fetal loss rate appears to be much lower than previously reported, whether the procedure is performed by an ob.gyn. or a perinatologist, a study of nationwide claims data revealed.
Ob.gyns. had a fetal loss rate of 1:327 and perinatologists a loss rate of 1:386 in a study tracking outcomes of 28,613 midtrimester amniocentesis procedures in a nationwide HMO database between January 1998 and August 2000.
The total fetal loss rate in the large study was reassuringly low, Dr. Joanne C. Armstrong reported in a poster presentation at the annual meeting of the American College of Obstetricians and Gynecologists. Education material provided by ACOG informs patients that about 1 in 200 amniocentesis procedures results in fetal loss.
Moreover, the difference in loss rates by specialty was statistically insignificant, said Dr. Armstrong of Aetna Inc., Hartford, Conn.
"Our purpose was to respond to a very small, very alarming study that suggested generalists have a much higher loss rate than perinatologists," she said in an interview. "We thought if that was true, it was very concerning."
She was referring to a controversial study by Dr. W.B. Blessed and associates of Providence Hospital, Southfield, Mich. (Am. J. Obstet. Gynecol. 184[7]:1340-42, 2001).
In that analysis, genetic amniocentesis loss rates were 1 in 46 procedures for ob.gyns., and 1 in 312 for perinatologists. Dr. Armstrong noted, as did others, that the Michigan study tracked results for only eight ob.gyns. and three perinatologists, all practicing in a single city. She and her associates at Aetna decided to see whether claims data might be able to clarify the issue by looking at results of a ...
Source: HighBeam Research, Amniocentesis fetal loss rate 1:327 for ob.gyns. (Earlier Study...