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Accelerated tocolysis lengthened triplet gestations. (Case-Control Study of 40 Women).
LOS ANGELES -- Accelerated dosing of continuous subcutaneous terbutaline in women bearing triplets who were at risk of preterm delivery extended gestation by nearly 2 weeks and decreased admissions to the neonatal intensive care unit, Dr. Gary Stanziano.
In a retrospective matched case-control study of 40 women pregnant with triplets, mean gestational age at delivery was 33.3 weeks in those who received accelerated dosing and 31.5 weeks in those managed with customary dosing. The accelerated dosing group also had a greater percentage of deliveries that occurred at 35 weeks' gestation or later (83% vs. 25%), he said at the annual meeting of the American College of Obstetricians and Gynecologists.
Infants in the accelerated dosing group were less likely to be admitted to the neonatal intensive care unit (46% vs. 82%) and spent less time there (11 days vs. 20 days). Birth weights were significantly higher in the accelerated dosing group, he said Dr. Stanziano of Stamford, Conn.
The women were told to restrict physical activity and were managed with a transvaginal ultrasound of the cervix and corticosteroids. Home uterine activity ...
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...results demonstrated that the 500mg dosing group significantly reduced the rate of atrial...was greater than 90 days for the 500mg dosing group, compared to 27 days for the placebo...analysis. 51% of patients in the 500mg dosing group (n=150) completed the study in normal...
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- Press release article from: PR Newswire March 17, 2008 700+ words
...efficacy benefit for the 500mg dosing group as compared to placebo (two...greater than 90 days for the 500mg dosing group, compared to 39 days for the...52% of patients in the 500mg dosing group (n=110) completed the study...
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...efficacy benefit for the 500mg dosing group as compared to placebo (two...greater than 90 days for the 500mg dosing group, compared to 39 days for the...52% of patients in the 500mg dosing group (n=110) completed the study...