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Maternal hypothyroidism linked to prematurity. (Severity at Term May be Key).
LOS ANGELES -- Women diagnosed with hypothyroidism during pregnancy were more likely to deliver preterm than euthyroid women, and the likelihood increased with rising serum TSH levels, Dr. Aikaterini Deliveliotou reported.
Mean serum levels of TSH at the last visit before delivery were significantly higher in women who delivered preterm than in those who delivered at term (10 [mu]IU/mL vs. 3 [mu]IU/mL). "Prematurity may be related to the severity of hypothyroidism near term," Dr. Deliveliotou said at the annual meeting of the Society for Gynecologic Investigation.
The investigators assessed prepartum and delivery data for 32 women diagnosed with subclinical hypothyroidism and 13 women diagnosed with clinical hypothyroidism between 1996 and 2001. Two women had spontaneous abortions. Eight of the remaining 43 women had other preexisting diseases, and 35 women had hypothyroidism alone, said Dr. Deliveliotou of the University of Southern California, Los Angeles.
Both the clinical and subclinical hypothyroidism groups were more likely to deliver before term, compared with a control group of 129 women with no known medical diseases matched with the study cohort for age, gravidity, parity, race, and birth year.
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