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Peptide promising as a breast Ca marker. (Prospective Study).
SAN FRANCISCO -- Plasma levels of C-peptide appear to correlate with breast cancer risk and may show potential as a blood marker for the disease, data from the Harvard Nurses' Study suggest.
The relative risk of breast cancer for women whose C-peptide levels were in the highest quintile was 68% higher than that of women in the lowest quintile, Dr. Celia Byrne said at the annual meeting of the American Association for Cancer Research. The risk rose steadily as C-peptide levels increased. In women who had high C-peptide levels and were premenopausal at the time their blood was drawn, the relative risk of breast cancer was 221% higher, compared with that of women in the lowest quintile.
C-peptide is the fragment left when proinsulin is cleaved to create insulin, Dr. Byrne explained. Although it is not clear whether C-peptide has any physiologic activity of its own, high levels are correlated with age, high body mass index, and a sedentary lifestyle, probably because those conditions are linked to greater insulin secretion. Physical ...
- Higher C-peptide levels increase mortality in breast cancer...
- Magazine article from: Women's Health Advisor March 1, 2008 700+ words
...times higher than breast cancer patients with lower C-peptide levels, according to...observational study of breast cancer patients. The...with higher C-peptide levels, the rate was...who had invasive breast cancer that had spread...
- Natriuretic Peptide Levels in Mitral Regurgitation.
- Magazine article from: Clinical Cardiology Alert August 1, 2003 700+ words
Natriuretic Peptide Levels in Mitral Regurgitation Abstract...explored the concept that natriuretic peptide levels (ANP, BNP) may aide in the determination...echocardiographic assessment and 3 natriuretic peptide levels measured. They also studied 100...
- Effect of interactions between C peptide levels and insulin treatment on...
- Magazine article from: Canadian Medical Association. Journal Ko, Gary T C; So, Wing-Yee; Tong, Peter C; Chan, Wing-Bun; Yang, Xilin; Ma, Ronald C; Kong, Alice P; Ozaki, Risa; Yeung, Chun-Yip; Chow, Chun-Chung; Chan, Juliana C April 28, 2009 700+ words
...insulin therapy in patients with higher C peptide levels. Results: The mean age of the cohort...Interpretation: Patients with low C peptide levels who received insulin had the best clinical...outcomes. Patients with normal to high C peptide levels who received insulin had the worst...
- Brain natriuretic peptide levels predict heart failure...
- Magazine article from: Internal Medicine News December 15, 2005 700+ words
...The mean age was 77 years. Researchers assessed heart rate, blood pressure, respiratory rate, and brain natriuretic peptide levels taken at enrollment for patients who were admitted within 30 days. "Admissions are an indication of how the patient is...
- B-type natriuretic peptide levels are associated with mitral regurgitation.
- Newspaper article from: Biotech Week June 23, 2004 700+ words
...colleagues published the results of their research in the American Journal of Cardiology (Comparison of B-type natriuretic peptide levels in patients with heart failure with versus without mitral regurgitation. Am J Cardiol, 2004;93(8):1002-1006...
- Atrial and brain natriuretic peptide levels rise in the ischemic myocardium.
- Newspaper article from: Angiogenesis Weekly November 12, 2004 700+ words
2004 NOV 12 - (NewsRx.com & NewsRx.net) -- Atrial and brain natriuretic peptide levels rise in the ischemic myocardium. "Angiogenic gene therapy in angina pectoris has been disappointing so far. Reasons might be...
- Clinical Briefs: Vitamins and RTI; B-Type Natriuretic Peptide Levels and Heart...
- Magazine article from: Internal Medicine Alert October 29, 2002 700+ words
...also due to a deleterious effect of vitamin E. Graat JM, et al. JAMA. 2002;288: 715-721. B-Type Natriuretic Peptide Levels and Outcome in Patients with Heart Failure Brain natriuretic peptide (BNP) levels reflect the degree of cardiac ventricular...
- Use of BNP to guide heart failure Tx reduced deaths.(Cardiovascular...
- Magazine article from: Internal Medicine News June 1, 2005 700+ words
ORLANDO, FLA. -- Use of serial plasma B-type natriuretic peptide levels to guide medical therapy for systolic heart failure was linked to significant reductions in heart failure-related deaths and...