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LOS ANGELES -- Even with advanced neonatal intensive care, few babies born after preterm premature rupture of membranes between 18 and 23 weeks' gestation survived in a study of 101 pregnancies, and most of the survivors struggled with severe health problems, Dr. Usha Verma said at the annual meeting of the Society for Gynecologic Investigation.
Many perinatologists offer expectant management to women with preterm premature rupture of the membranes (PPROM) in the early second trimester in hopes of prolonging gestation, but management of these cases is controversial. How the physician counsels the patient is an important factor. Patients with PPROM in this time period should be told that the babies are likely to die and that "if they survive, almost every one is going to be really sick for a long time," said Dr. Verma of the University of Miami.
The study included all women who presented with PPROM between 18 and 23 weeks' gestation at his institution over a 2-year period; 15% survived.
None of 21 ...