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Tocolytics after PPROM linked to earlier delivery: may cause or initiate premature labor. (Magnesium Sulfate).
LOS ANGELES -- Women who received magnesium sulfate after preterm premature rupture of membranes in hopes of extending gestation long enough to receive prenatal steroids actually delivered sooner than their counterparts who weren't on tocolytics, Dr. Allahyar Jazayeri reported.
In a retrospective study of 72 women with preterm premature rupture of membranes (PPROM) a significantly greater percentage of babies whose mothers received magnesium sulfate delivered within 48 hours (47% vs. 22%) and within 1 week (92% vs. 44%) of rupture than those whose mothers weren't on tocolytics. Delivery rates within 24 hours of rupture were not significantly different between groups, he said at the annual meeting of the Society for Gynecologic Investigation.
"We really were not expecting to see that the patients who received magnesium sulfate delivered early Even though theoretically you would think magnesium sulfate would benefit these patients, it might actually harm the pregnancy by causing or initiating premature labor," said Dr. Jazayeri, director of maternal and fetal medicine at Texas Tech University, Lubbock.
The use of tocolytics after PPROM is controversial. Guidelines from the American College of Obstetricians and Gynecologists say that it's not clear whether patients benefit from 48 hours of tocolytics after PPROM. The study is one of the first to look at the use of tocolytics after PPROM. Approximately one-third of all premature deliveries involve PPROM.
Some studies that have appeared in the microbiology literature show that magnesium is an essential nutrient for bacteria to grow in culture media. Magnesium sulfate and other magnesium salts also have been associated with increased bacterial virulence and resistance to ...
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Source: HighBeam Research, Tocolytics after PPROM linked to earlier delivery: may cause or...