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Dramatic psychiatric symptoms have been reported occasionally in patients taking nonsteroidal anti-inflammatory drugs.
Symptoms usually resolve promptly when the drugs are discontinued, but in at least one scenario--the concurrent use of an NSAID with lithium--severe toxicity is a danger. NSAIDs markedly reduce lithium clearance, increase blood levels, and can lead to toxicity within 2-3 days, Dr. Norman Sussman said.
The reports in the literature "are anecdotal and do not establish a causal role for NSAIDs," said Dr. Sussman of New York University at a conference on psychopharmacology sponsored by the university.
One report described four patients who developed moderate to severe depression (accompanied by paranoia in one case) on NSAID therapy which remitted when the drug was discontinued and returned when the drug was restarted in three of the cases.
Five case reports involved psychiatric outpatients (with major depressive disorder, bipolar disorder, ...
Source: HighBeam Research, NSAIDs Side Effects. (Mental Health).