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C. difficile Colitis Gets Tough. (GI Disorders).
Clostridium difficile colitis appears to have become an increasingly aggressive infection since the mid-1990s, Dr. Arden Morris said at the annual meeting of the American Society of Colon and Rectal Surgeons.
The incidence of C. difficile colitis and its associated mortality has skyrocketed since the mid-1990s at Oregon Health Sciences University, Portland, said Dr. Morris, a colorectal surgeon at the university. Moreover, the outcomes of the infection in immunologically intact patients were no better than in patients who were profoundly immunosuppressed or debilitated by chronic renal disease or diabetes.
Evidence that the clinical course of this disease is changing for the worse came from a retrospective chart review of all 157 patients with laboratory-confirmed C. difficile colitis at the university medical center during 1994-2000. Disease trends were compared with those ...
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