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Raloxifene May Block L-Thyroxine Absorption. (Take the Drugs at Different Times).
SAN ANTONIO - Patients taking raloxifene and L-thyroxine should be advised not to take the two drugs at the same time, Dr. Elias S. Siraj said at the annual meeting of the American Association of Clinical Endocrinologists.
Dr. Siraj of the Cleveland Clinic reported the case of a 79-year-old woman who required increasing doses of L-thyroxine to manage her symptoms of hypothyroidism after initiating raloxifene therapy. Her case and a subsequent study documented malabsorption of L-throuxine when the drug was taken at the same time as raloxifene. Taking the two drugs at different times of the day did not impair L-thyroxine absorption.
The patient's primary hypothyroidism had been well managed for many years at a dosage of 0.15 mg/day of L-thyroxine. She had undergone a subtotal thyroidectomy 30 years before for benign thyroid nodules.
She had been prescribed 60 mg/day of raloxifene, marketed as Evista, for osteopenia. She took the raloxifene early in the morning, at the same time that she took her daily dose of L-thyroxine.
At noon she took sertraline, hydrochlorothiazide, ferrous sulfate, and a multivitamin. She received monthly [B.sub.12] injections. Ferrous sulfate is known to inhibit absorption of L-thyroxine, as are several other medications including sucralfate, cholestyramine, colestipol, and aluminum-containing antacids.
Also of potential relevance, the patient had a history of ...
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Source: HighBeam Research, Raloxifene May Block L-Thyroxine Absorption. (Take the Drugs at...