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Luteal Phase Fluoxetine Dosing Improves PMDD. (A Higher Dose Appears Better).
NEW ORLEANS - Luteal phase dosing with fluoxetine was effective in treating mood and physical symptoms of premenstrual dysphoric disorder, according to several poster presentations at the annual meeting of the American Psychiatric Association.
In a randomized, placebo-controlled study of 260 women, luteal phase dosing with fluoxetine (Prozac, Serafem) 20 mg daily significantly improved total scores and subscale scores for mood symptoms, physical symptoms, and social functioning on the Daily Record of Severity of Problems (DRSP), compared with placebo, said-Dr. Cherri Miner of Lilly Research Laboratories, Indianapolis. Luteal phase dosing with fluoxetine 10 mg daily significantly improved mood and social functioning sub-scale scores, compared with placebo.
Following a two-cycle screening period and a one-cycle single-blind placebo period, the subjects received luteal phase dosing with fluoxetine 10 mg or 20 mg daily or placebo for three cycles. Subjects used the DRSP to record PMDD symptoms daily.
Fluoxetine 20 mg daily improved the ...
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Source: HighBeam Research, Luteal Phase Fluoxetine Dosing Improves PMDD. (A Higher Dose Appears...