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New Intrauterine Device Has Noncontraceptive Benefits. (Relieves Dysfunctional Bleeding).
SEA ISLAND, GA. - The recently approved Mirena IUD has several noncontraceptive benefits, including the reduction of dysfunctional uterine bleeding and the protection of the endometrium for women on estrogen therapy.
"These noncontraceptive uses would be off-label uses, but they have already been proven to work in Europe," where the device has been used for more than 20 years, Dr. Ian Thorneycroft said at an ob.gyn. meeting sponsored by the Medical College of Georgia.
The device delivers 20 mcg of levonorgestrel per day and lasts for 5 years. It has an overall contraceptive failure rate of 0.14 per 100 woman-years-a rate comparable to that of tubal ligation-but has the added benefit of being reversible, said Dr. Thorneycroft, a paid consultant to Berlex Laboratories, the maker of the IUD, and a professor of obstetrics and gynecology at the University of South Alabama, Mobile.
Mirena works by inhibiting fertilization through several mechanisms: It thickens the cervical mucus, inhibits sperm motility and function, inhibits ovulation in some cycles, and suppresses the endometrium.
It is the suppression of the endometrium that produces the device's noncontraceptive benefits. Because there is no proliferation of the endometrial lining, menstrual blood loss is significantly reduced, compared with other ...
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