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Soy Benefits Blood Pressure, Lipids, and Bone.

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| September 15, 2001 | JANCIN, BRUCE | COPYRIGHT 2001 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

DENVER -- Dietary soy consumption has favorable effects on blood pressure, lipids, and biochemical markers of bone turnover in postmenopausal women- and unlike oral estrogen, soy doesn't activate coagulation, Dr. Helena J. Teede said at the annual meeting of the Endocrine Society.

The picture that emerges from these studies is that soy containing isoflavones continues to be highly worthy of further investigation as a possible alternative to postmenopausal estrogen for prevention of osteoporotic fractures as well as for cardioprotection, according to investigators.

Dr. Teede of Monash University in Melbourne, Australia, reported on 42 healthy postmenopausal women who were randomized to 40 g of soy protein per day containing 118 mg of isoflavones or to casein placebo. In the 3-month, double-blind study of the phytoestrogens' effects on the hemostatic system, the amount of soy consumed was equivalent to the typical dietary soy intake in Japan, where cardiovascular disease rates are far lower than in the Western world, she noted.

The study followed her earlier published study on the hemostatic effects of oral estrogen replacement therapy in 42 healthy postmenopausal women. That study showed that although estrogen improved lipid profiles, it also had undesirable prothrombotic effects. The failure of HRT to prevent cardiovascular events in the Heart and Estrogen/Progestin Replacement Study trial may have been due to estrogen's tendency to cause arterial thrombosis, she said.

Soy phytoestrogens bear structural similarity to estrogen, but they do not appear to share estrogen's unwelcome prothrombotic proclivity.

Soy consumption was associated with significant reductions in levels of LDL and triglycerides, compared with baseline. For example, ...

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