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Higher-Than-Normal Doses OK During Methadone Maintenance Therapy.

OB GYN News

| August 15, 2001 | MACREADY, NORRA | COPYRIGHT 2001 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

LOS ANGELES -- Babies born to women who take higher-than-recommended doses of methadone during the third trimester are no more likely to experience withdrawal than are the children of women who take the standard dose, Dr. Peter Selby said at the annual meeting of the American Society of Addiction Medicine.

In a review of the records of 53 women maintained on methadone who delivered at St. Joseph's Health Centre in Toronto between 1994 and 2000, Dr. Selby and his associates found no differences in fetal outcomes when they compared babies born to women who received more than 100 mg of methadone per day with those born to women who got the recommended daily dose of less than 100 mg. Of the women in the study, 26 received a mean daily dose of 64 mg methadone and 27 received a mean daily dose of 132 mg.

There were no significant differences in birth weight, head circumference, gestational age, delivery method, incidence or duration of neonatal withdrawal, or length of hospital stay. There were no hospital readmissions in either group.

Methadone maintenance therapy is the standard of care for pregnant opioid addicts, Dr. Selby said. It is associated with decreased infant mortality, larger head circumference, and fewer premature births. The current recommendation is that doses not exceed 100 mg/day in the third trimester to avoid inducing ...

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Source: HighBeam Research, Higher-Than-Normal Doses OK During Methadone Maintenance Therapy.

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